Course on Protein aggregation at IIT Bombay [Sept 17-21]: Register by Aug 31: Expired

About

Proteins are the workhorses in cellular machinery and perform a wide array of functions in our body for our survival. However, for proteins to function properly, they must be folded correctly into a three-dimensional conformation. During in-vivo protein folding, non-native conformers of protein can also arise due to various reasons such as alteration in primary structure (e.g., mutation), altered post-translational modifications and environmental conditions, which may lead to protein aggregation and diseases. Furthermore, the partial unfolding of proteins can also happen due to thermal and oxidative stress.
All these can induce non-native conformations of the protein, which can oligomerize and form protein aggregates. Protein aggregates can be either amorphous or can have ordered structure like amyloid fibrils. The accumulation of such stable and insoluble protein aggregates is often linked to neuronal degeneration and other protein deposition disorders.

Therefore, for designing therapeutics, the exact mechanism of protein aggregation should be clear. Moreover, protein aggregation is an important aspect for regulatory agencies and the biopharmaceutical industry for developing protein/peptide drugs for human welfare. Protein aggregation during drug formulation often introduces adverse effects in the patients.

Topics
  • Principle of protein folding in vitro and in vivo
  • Protein structure and structure-function relationship
  • The principle involved in protein misfolding and aggregation
  • Techniques in studying protein folding, misfolding and aggregation
  • Analytical techniques for predicting and analyzing protein aggregates in solution
  • Case studies of protein aggregation associated with disease, function and drug formulation
  • Demonstration of structural and biophysical techniques for studying protein aggregation in solution.
Who can Attend?

Students/faculties who would like to start their research in protein chemistry, biophysical characterization of protein and protein folding. Students/faculties are interested in studying protein aggregation associated with various human diseases and protein formulations. Scientists in academia and industries working with protein/peptide therapeutics and formulation.

Registration

To register online, click here.
The last date to register is August 31, 2019.

Contact

Phone Number: 022 2572 2545

For further details, click here.

Subscribe to our newsletter


Leave a Reply

Your email address will not be published. Required fields are marked *